Best CBD Edibles ‌‌|‌‌ CBDNerds.com 2020 Within the CBD market, edibles have attracted a lot of attention and have grown a loyal following of customers. They are easy to consume, provide a familiar feel for newcomers, and are effective at delivering cannabidiol to our bodies. But with so many of these products on the market, it can be hard to determine what the best CBD edibles are.   From gummies to honey sticks to chocolate bars, there is something for every taste when it comes to CBD edibles. Furthermore, new edibles are constantly being developed and released to continually provide you with new flavorful CBD experiences.   In order to decide on the best CBD edibles, we chose companies that offer either high-quality products or a wide selection of edibles. If you are interested in any of these delicious treats, we also offer coupon codes for each company to help you save on your orders!   Top Ranking CBD Edibles 1.) Diamond CBD Rating 5/ 5 Extract Type: Full-spectrum Total CBD Range: 75mg - 1,000mg Potency Range: 12.5mg Price Range: $9.99 - $300.00 Value ($/mg): $0.11 - $0.30 per mg THC Content: <0.3% Lab Report: See Here Edible Variations: 106 Potency Variations: 5   Diamond CBD Pros: Offer CBD edibles from an assortment of brands Largest variety of edibles on our list   Diamond CBD Cons: Large collection of CBD edibles could be overwhelming for newcomers   If you’re looking for a company that offers enough CBD edibles for you to continuously come back to, look no further than Diamond CBD. Do not just take our word for it, take one look at their 15-page edibles selection and see for yourself.   One advantage Diamond CBD has over other companies is its partnership with several CBD brands, including Yum Yum Goodies and Chong’s Choice. This allows them to sell and distribute an assortment of CBD edibles, from gummies to honey sticks to caramel apples. Each edible is offered in a variety of flavors, so there is bound to be something here for all tastes and all users.   The only downside to Diamond CBD is that their products can be expensive. Moreover, due to their large assortment, it can be difficult to find the right potency for you. As a final note, keep in mind that the table of facts presented here is only reflective of the CBD edibles offered by Diamond CBD themselves.   2.) Lord Jones Rating 5/ 5 Extract Type: Broad-spectrum Total CBD Range: 100mg - 180mg Potency Range: 20mg per edible Price Range: $30.00 - $60.00 Value ($/mg): $0.30 - $0.33 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 6 Potency Variations: 1   Lord Jones Pros: Their CBD edibles can be purchased in a bundle-pack with other products Some of the highest-quality products on our list Free shipping on all orders   Lord Jones Cons: Most expensive company on our list   Seeing as Lord Jones can be an expensive brand, it is no surprise that they have built a reputation for developing some of the most luxurious CBD products currently on the market. Their collection of CBD gumdrops is no exception to that.   Each purchase comes neatly wrapped in a box of 9 gumdrops - each containing 20mg of broad-spectrum CBD. These gumdrops can be purchased in a few different flavors, including a standard taste, Prickly Pear, Grapefruit, Blood Orange (limited edition), Sigurberry (limited edition).   In addition to these edibles, Lord Jones also offers a box of 5 CBD dark chocolate espresso chews. While the name may lead you to assume these could be ideal for waking up in the morning, many reviews on Lord Jones’ website instead indicate that they’re perfect for relaxing at the end of the day. Each chew comes with 20mg of broad-spectrum hemp extract.   3.) Fab CBD Rating 4/ 5 Extract Type: Isolate Total CBD Range: 750mg Potency Range: 25mg per gummy Price Range: $59.00 Value ($/mg): $0.07 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 1 Potency Variations: 1   Fab CBD Pros: CBD gummies are vegan, gluten-free, and made with all-natural ingredients Known for their high-quality CBD products and good value   Fab CBD Cons: Only offer CBD gummies   While Fab CBD might not have the biggest selection of CBD for oral consumption, their gummies are of such prime quality that it’s hard to leave them out of a conversation about the best CBD edibles. Each gummy is made with all-natural ingredients (including the fruit flavoring) and is vegan-friendly and gluten-free.   Fab CBD’s blend contains a CBD isolate extract meaning that these gummies have absolutely no THC in them. This is ideal for users who may have to take a drug test or may simply prefer to avoid THC altogether for other reasons.   Each gummy contains 25mg of CBD isolate which should produce deeply relaxing effects. Some have reported using these gummies for muscle relief after a hard workout, whereas others have found them beneficial for getting a better night’s sleep. Whatever your reason may be for buying Fab CBD’s edibles, you will find them to be some of the most affordable products currently on the market – providing excellent value for your money!   4.) Hemp Bombs Rating 4/ 5 Extract Type: Broad-spectrum Total CBD Range: 75mg - 3,000mg Potency Range: 15mg - 75mg per edible Price Range: $14.99 - $169.99 Value ($/mg): $0.05 - $0.19 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 5 Potency Variations: 5   Hemp Bombs Pros: Offer a variety of edibles, including gummies, capsules, shots, syrups, and lollipops Excluding the shots and lollipops, all of Hemp Bombs’ edibles can be purchased in different potencies CBD gummies and CBD capsules can be purchased in different sizes   Hemp Bombs Cons: Price per milligram can vary depending on which edible you purchase (for example, buying gummies is a better deal than purchasing CBD lollipops)   Hemp Bombs do not shy away from experimenting with different CBD-infused edibles. While they do offer your standard gummies and capsules, they have also developed and currently sell three products that are considered unique within the industry.   The first is their CBD shot, known as the “Max Chill CBD Shot.” Each $14.99 purchase comes with 75mg of CBD and is designed for on-the-go relief. The second is a concentrated CBD syrup that is available in two different potencies: 300mg or 1,000mg total. The CBD syrup with its fruit punch flavor, is the perfect mixer for any kind of beverage. Finally, Hemp Bombs also offer CBD lollipops. Each lollipop contains 25mg of CBD and sold in a four-pack containing the following flavors: cherry, green apple, pink lemonade, and watermelon.   If these unparalleled edibles do not spark your interest, you can always opt for Hemp Bombs’ selection of gummies and capsules. These products are available in normal-strength and high-strength potencies and can be purchased in a variety of sizes (from a 30-count to 100-count).   5.) Green Roads Rating 4/ 5 Extract Type: Broad-spectrum and Isolate Total CBD Range: 25mg - 750mg Potency Range: 10mg - 50mg per edible Price Range: $3.25 - $49.99 Value ($/mg): $0.06 - $0.13 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 11 Potency Variations: 4   Green Roads Pros: Offer a wide variety of edibles - including on-the-go CBD products Free 2-day shipping for orders of $50 or more   Green Roads Cons: Small size variations (only goes up to 30-count on select edibles)   Green Roads have made a name for themselves through their edible selection. Particularly, for their CBD gummy selection which comes in a variety of shapes like gummy bears, froggies, and bites. Each of these gummies can be purchased in an assortment of potency ranges, from 10mg to 50mg per gummy. Additionally, Green Roads now offers nighttime gummies made with melatonin to promote a better night’s rest.   Another popular product line by Green Roads is their selection of CBD capsules. These include their standard soft gel, a relax capsule infused with GABA and 5-HTP, and their sleep capsules made with melatonin. All three options are made using a CBD isolate blend with 25mg per capsule (750mg total).   Green Roads have also developed some unique CBD edibles like their CBD chocolate bar. Made with 180mg of CBD isolate and all-vegan ingredients, this little treat is perfect for those looking for a mild CBD experience. Finally, it is worth mentioning that Green Roads also offers a CBD coffee which is ideal for those looking for a morning pick-me-up.   6.) cbdMD Rating 4/ 5 Extract Type: Broad-spectrum Total CBD Range: 300mg - 3,000mg Potency Range: 10mg - 50mg per edible Price Range: $29.99 - $149.99 Value ($/mg): $0.05 - $0.10 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 5 Potency Variations: 6   cbdMD Pros: All gummies are vegan-friendly Offer a CBD gummy with a vitamin C blend cbdMD is a member of the U.S. Hemp Roundtable   cbdMD Cons: Only offer CBD gummies and CBD capsules/soft gels   While cbdMD may not offer the largest edible variety, they have some of the top-quality CBD products currently on the market.   Their first kind of edibles on offer is their CBD gummy line. These vegan treats contain 10mg to 50mg per gummy (300mg - 1,500mg total) of broad-spectrum hemp extract. Additionally, cbdMD offer a gummy formulated with both 25mg of CBD and a dose of vitamin C which has been reported to help protect cells and can help boost our immune system   Beyond gummies, cbdMD also offers a selection of both capsules and soft gels. These can be purchased in 30-count or 60-count bottles and come in potencies ranging from 15mg to 50mg. Furthermore, they also offer a “PM” capsule that has a dose of melatonin to promote better sleep.   7.) Just CBD Rating 4/ 5 Extract Type: Isolate Total CBD Range: 250mg - 3,000mg Potency Range: 8mg - 25mg per edible Price Range: $12.99 - $150.00 Value ($/mg): $0.03 - $0.15 per mg THC Content: 0.0% Lab Report: See Here Edible Variations: 19 (not including flavors) Potency Variations: 5   Just CBD Pros: Large selection of edible varieties CBD gummies come in a variety of flavors CBD capsules come in different formulas made for different uses   Just CBD Cons: CBD potency in gummies is not clear   Just CBD offers what may be the most diverse selection of CBD edibles on our list. While they sell your standard CBD capsules and gummies, they also offer CBD honey sticks and CBD cocoa quinoa bites.   In addition to the wide variety of flavors their CBD gummies come in, Just CBD’s selection of capsules is also very interesting. Each capsule is made with several all-natural ingredients to promote therapeutic benefits for certain health conditions. For example, their energy formula has a multitude of vitamins to help you wake up in the morning.   If you’re looking for a unique CBD edible you will not find anywhere else, we definitely suggest giving Just CBD’s cocoa quinoa bites a try. Each of these is made using a total of 250mg of CBD along with delicious bittersweet chocolate.   Finally, Just CBD also offers a selection of vegan-friendly edibles for you to choose from.   8.) Blue Ridge Hemp Rating 3.5/ 5 Extract Type: Isolate Total CBD Range: 60mg - 250mg Potency Range: 15mg - 60mg per serving Price Range: $15.00 - $40.00 Value ($/mg): $0.16 - $0.25 per mg THC Content: 0.0% Lab Report: None Edible Variations: 6 Potency Variations: 3   Blue Ridge Hemp Pros: Offer some of the most interesting CBD edibles and often have limited-time releases All edibles are vegan Use an isolate extract to guarantee the absence of THC   Blue Ridge Hemp Cons: More expensive compared to competitors on a per milligram (mg) basis No certificates of analysis available   Marketing them as CBD superfoods, Blue Ridge Hemp offers one of the most unique selections of CBD edibles on the market. They offer a range of coconut oils along with their “CBD Alchemy Adaptogenic Mushroom Chocolate Bar” and the limited edition “Half Baked Strawberry Hemp Heart Pretzel Bars.”   Blue Ridge Hemp’s coconut oils are their mainstay and come in a variety of flavors, including Pumpkin Spice, Dark Chocolate, Golden Spice, and Standard. While coconut oils are traditionally used for topical treatments, they can be beneficial through oral consumption as well.   Furthermore, the reason Blue Ridge Hemp really shines on our list is for their specialty edibles. The company takes it upon themselves to innovate and develop new delicious goodies, all of with a familiar homemade feel to them. They also offer a CBD Alchemy Apaptogenic Mushroom Chocolate Bar which is vegan and gluten-free. For the month of October, they are also currently offering a CBD Pretzel Bar. We suggest you keep up with Blue Ridge Hemp to stay up to date on their latest goodies!   The only downside to these products is the fact that Blue Ridge Hemp does not offer any certificates of analysis (CoA) for their edibles. However, their CBD flower (which can be purchased separately) has CoAs on their individual product pages.   9.) R+R Medicinals Rating 3.5/ 5 Extract Type: Full-spectrum Total CBD Range: 510mg - 1,020mg Potency Range: 15mg - 30mg per edible Price Range: $25.99 - $45.99 Value ($/mg): $0.04 - $0.05 per mg THC Content: <0.3% Lab Report: See Here Edible Variations: 2 Potency Variations: 3   R+R Medicinals Pros: Use all-natural ingredients Many positive reviews on R+R Medicinals website Offer a monthly subscription service to help you save   R+R Medicinals Cons: Only offer gummies and soft gels   If you are in the market for a CBD edible rich in terpenes, flavonoids, antioxidants, and phytonutrients, look no further than R+R Medicinals. They offer a CBD gummy and a CBD soft gel variety - each made with a full-spectrum hemp extract. This type of extract is ideal for those looking to experience an entourage effect from consuming their CBD products.   The CBD gummies are each made with 25mg of CBD and come in a 30-count bottle that gives you roughly a 30-day supply of CBD. According to reviews on R+R Medicinals website, these gummies have helped promote relaxation and were also great at pain relief.   The other edible R+R that Medicinals offer is a CBD soft gel sold in two potencies - 15mg or 30mg per soft gel. These supplements are made using MCT coconut oil which allows for a higher absorption rate and comes packaged in a 34-count bottle of soft gels.   Another thing we like about R+R Medicinals is their price point as they offer some of the least expensive CBD edibles on our list. In addition to that, you can also opt into a monthly subscription service to help you save further on each purchase.   10.) Verma Farms Rating 3.5/ 5 Extract Type: Broad-spectrum Total CBD Range: 250mg - 500mg Potency Range: 10mg - 21mg per edible Price Range: $44.99 - $59.99 Value ($/mg): $0.11 - $0.17 per mg THC Content: 0.0% Lab Report: Must email to receive Edible Variations: 13 Potency Variations: 2   Verma Farms Pros: All edibles come in tropical flavors Only company on our list that offers CBD Dried Fruit   Verma Farms Cons: No certificates of analysis on website   Verma Farms currently offers two types of edibles - CBD gummies and CBD dried fruit. Both types are made using a tropical flavor that perfectly fits the company’s location in Hawaii.   For their CBD gummies, Verma Farms currently offers Peachy Pau, Maui Melon, Blueberry Wave, Beary Beach, Hawaiian Rainbow, Wahoo Worm, Island Apple, Tropical Cherry, Rainbow Worm, and Sugar-Free. Their gummies typically come in a 20-count package and contain 250mg total CBD (about 12.5mg per gummy), with a select few flavors coming in a 500mg total CBD package (giving you 25mg per gummy).   Verma Farms also offers CBD-infused dried fruit, these can be purchased in Maui Mango, Rainbow Papaya, and Pineapple Party flavors. Each piece of their dried fruit contains about 12.5mg of broad-spectrum CBD per piece (250mg total).   The biggest downside we found to Verma Farms is that they are not as transparent with their certificates of analysis as other companies - you must email them to receive this information. However, since their customer service tends to be exceptional, we believe you would be able to get access to the lab test result if you email and ask for it.   What Are CBD Edibles? Cannabidiol (CBD) edibles are food or beverage products that are infused with CBD extracted from the hemp plant. These products are developed as an alternative method for consuming CBD that does not involve smoking, vaping, or the use of tinctures. CBD is added to these products as one of the following CBD extract types:   Full-Spectrum - Contains all the cannabinoids found within the cannabis plant.   Broad-Spectrum - Contains all the cannabinoids found in the cannabis plant except for tetrahydrocannabinol (THC).   CBD Isolate - Purely CBD and no other cannabinoid.   There are many different CBD edibles products currently on the market, the most common types are CBD gummies and CBD capsules. Even though tinctures can also be considered edibles, we didn’t include them on this list as we already have an article discussing the best CBD oils.   How Are CBD Edibles Made? Making CBD edibles is quite simple. Companies must first extract the cannabinoid out of a high-CBD plant and then include it in preparing various edible items. The types of foods and beverages that CBD is combined with can widely vary depending on the company. In all cases, however, reputable brands will seek to only include all-natural ingredients and make sure their products are safe for those with food restrictions or allergies.   Are CBD Edibles Legal? Yes! Under the 2018 Farm Bill, CBD and hemp were federally legalized with a few restrictions. The most notable being that for a cannabis plant to be defined as hemp, it must contain less than 0.3% THC.   If you are concerned that CBD edibles will get you high, it’s important to understand that <0.3% is such a low amount that it’s unlikely to cause psychoactive effects. Only in rare cases, have some people felt mild psychoactive effects typically associated with THC.   It’s important to note that if you live in a state where cannabis is recreationally legalized, you may run into CBD edibles that have a higher concentration of THC. Therefore, when buying CBD products in these locations, it helps to verify the contents of your CBD edible before each purchase.   What Do CBD Edibles Do? While CBD affects everyone differently, it is likely to make your body and brain feel relaxed. When we consume CBD, it has an effect on our endocannabinoid system (ECS). Though researchers still are not 100% certain of how this works, it is hypothesized that CBD helps keep our ECS in a state of homeostasis and optimal physiological conditions.   Due to CBD’s effect on our ECS, there are several potential therapeutic benefits to consuming CBD edibles. These may include:   Alleviates anxiety and depression Alleviates nausea and vomiting Inhibits cancer cell growth Pain relief (including chronic pain) Promotes bone growth Promotes better and more restful sleep Reduces seizures and convulsions Reduces blood sugar levels Reduces risk of artery blockage Reduces small intestine contractions Slows bacterial growth Suppresses muscle spasms   One aspect of CBD edibles that differs from other consumption methods is that cannabidiol processes through the digestive tract. Therefore, the effects usually take longer to be noticed (anywhere between 30 to 60 minutes). However, the effects typically last for a much longer period of time (anywhere between 8 to 12 hours).   How to Use CBD Edibles CBD edibles are probably the simplest form of CBD to use as they provide a familiar way to consume CBD. While different edibles require different consumption methods, all you must do is eat these delicious treats in order to feel the effects. Even though certain CBD edibles, such as CBD lollipops or CBD beverages aren’t exactly eaten, their effects are almost identical to any other CBD edible.   Keep in mind that different CBD edibles have different ways of measuring dosages. CBD gummies or capsules are the most convenient as you can identify the dosage in a single serving on a per gummy/per capsule basis. However, certain edibles like a CBD chocolate bar may require you to break apart the edible and eat it in sections.   In order to get an idea of how much of an edible you should take, we highly advise you to look at the “suggested use” on your product’s label.   Why Do People Enjoy CBD Edibles? People enjoy CBD edibles for different reasons. As mentioned, these treats provide many users with a familiar way to consume CBD. In other words, eating a CBD gummy may sound more appealing than taking CBD oil or puffing on a CBD vape.   Furthermore, CBD edibles are made in many different flavors. This provides consumers with a wide variety to choose from should they get tired of a particular taste. Beyond the flavor, CBD edibles also have the longest-lasting effects making them ideal for those who need constant relief.   Finally, CBD edibles are discreet compared to other consumption methods. They are easy to quickly consume whether on-the-go or stuck in the office. If you want to try CBD but are skeptical as to how those around you will view it, a CBD edible is the perfect way to hide the fact that you’re consuming a cannabis product.   Our Criteria for the Best CBD Edibles In order to decide what were the best CBD edibles out there, we made sure to have a set of criteria when developing this list. If you plan to purchase a CBD edible that is not on our list, we highly suggest you consider evaluating the product through our criteria first.   Certificate of Analysis - Since the CBD industry is unregulated, many companies go to a 3rd-party lab in order to receive a non-biased lab report on their products. These results will indicate several aspects of the CBD, including its cannabinoid-count, its purity, and whether it contains contaminants, such as pesticides. If you aren’t sure how to read a certificate of analysis, we invite you to check out our article on how to read CBD lab results.   Extract Type - There are three types of CBD extracts: full-spectrum, broad-spectrum, and isolate. In order to create a diverse list, we made sure to include products from each of these extract types.   Hemp Source - Most CBD within the United States comes from hemp. It is, therefore, vital for you to make sure a company is transparent about where they’re getting their hemp and whether or not it’s grown organically.   Ingredients - We understand there are many out there with food allergies that would like to try CBD edibles. CBD brands must indicate everything that goes into their products. We highly suggest looking at the ingredients used in a CBD edible in order to make sure they meet your dietary requirements and don’t cause you any allergic reactions.   Potency - The potency of CBD products is usually measured in milligrams (mg). The higher the milligram-count, the more CBD is in a product and the fewer servings you will need to feel the desired effects. If you are new to CBD, we suggest finding a product with anywhere from 10mg to 25mg per serving to start.   Safety and Side Effects of CBD Edibles While CBD is often celebrated for having no side effects, some users have reported feeling mild bouts of the following:   Appetite changes Diarrhea Drowsiness Dry mouth Fatigue   When it comes to CBD edibles, it is extremely important for you to make sure these products meet your dietary requirements. If you struggle with a food allergy, you should always check the ingredients put into each of these products.   If you are currently on prescription medication, we suggest consulting your doctor before taking CBD. While it is rare, there is some medication that has been reported to have negative interactions with CBD.   If you are currently pregnant or lactating, we also suggest that you do not take CBD. Unfortunately, there’s just not enough evidence suggesting women of this category are safe to consume CBD products.   Frequently Asked Questions How Long Do CBD Edibles Take? The effects of a CBD edible tend to kick in about 30 to 60 minutes after consumption. From there, effects will last anywhere from 8 to 12 hours. Also, there is no right or wrong time to take CBD.   Where Can I Buy CBD Edibles? While you can purchase CBD edibles in several locations, users should be aware of the fact that this industry is unregulated and, therefore, there will likely be several brands that don’t provide high-quality products. For this reason, we highly suggest purchasing from one of the brands mentioned here as these are the best CBD edibles out there. As an added bonus, you can use one of our coupon codes to help you save on your order!   Will CBD Edibles Get You High? No! Since CBD products must contain less than 0.3% THC, it is extremely unlikely you will get high from them. However, if you live in a state where recreational cannabis is legalized, you may run into CBD edibles that contain a higher concentration of THC.

    Scientific Confidence Grade Effect Size Rating Editorial Note C ** CBD may help relieve the symptoms and underlying causes of psoriasis. However, much of the evidence is limited to test-tube studies. There’s only one, low-quality human study.       CBD for Psoriasis: Can It Help? Early research suggests that CBD may have a positive effect on psoriasis. These findings highlight the involvement of the body's endocannabinoid system (ECS) in overall skin health. However, it remains too early to tell whether or not you should use CBD for psoriasis over traditional medication.   Psoriasis is a common skin condition characterized by scaly, itchy patches of skin. It’s usually treated by topical creams and ointments, but the condition is not curable and standard treatments are not always effective.   That’s why many people turn to alternative options such as cannabis and hemp-derived cannabidiol (CBD) products.   Research suggests that CBD may alleviate the symptoms of psoriasis and perhaps even address the overactive immune responses that underlie this condition. In particular, it seems that applying CBD topically may have a positive effect.   Here’s what the science says about the potential of using CBD for psoriasis.   Psoriasis Overview Psoriasis is an autoimmune skin disorder that causes red, itchy marks covered by flaking silvery scales. It most commonly affects the knees, elbows, scalp, and torso.   Health experts believe the main cause of psoriasis is the rapid growth of skin cells resulting from an overactive immune system. [1] Psoriasis is a chronic condition that goes through cycles of flaring up and receding.   Psoriasis Subtypes There are several types of psoriasis: [2]   Plaque psoriasis (psoriasis vulgaris): the most common type of psoriasis (90% of cases), distinguished by raised, red, itchy patches covered in white scales.   Inverse psoriasis: inflamed, shiny marks that occur in areas where your skin folds, such as the armpits, groin, and the inner thighs.   Guttate Psoriasis: this type of psoriasis is marked by small red spots and tends to affect children and adolescents.   Pustular Psoriasis: characterized by red, scaly patches with pustules that affect the hands and feet.   Erythrodermic psoriasis: a short-term condition distinguished by red, inflamed skin present on over 90% of the body. It can occur in any type of psoriasis as a result of sunburn, certain medications, and other factors.   Some people also develop psoriatic arthritis, a form of arthritis that occurs in about 20% to 30% of psoriasis sufferers.   Psoriasis Symptoms and Pathology The most common symptom of psoriasis is raised, red, flaky skin patches. These patches can be small in size or affect large areas. Psoriasis can also cause soreness, itching, and burning around the spots, pitted nails, and dry, cracked skin that can bleed.   These symptoms are worst during a flare-up and can disappear completely when psoriasis subsides.   Can CBD Help With Psoriasis? There’s a growing number of test-tube studies suggesting that CBD may have a positive effect on psoriasis.   One 2007 study looked at the effects of CBD, THC, and other cannabinoids on keratinocytes: the skin cells whose rapid growth — what scientists call proliferation — is the main cause of psoriasis.   All of the cannabinoids reduced keratinocyte proliferation, leading the researchers to conclude that there’s a “potential role for cannabinoids in the treatment of psoriasis.” [4]   More recently, the authors of a 2017 paper proposed that cannabinoids can help with psoriasis by addressing two key processes involved in its development: inflammation and angiogenesis, the formation of new blood vessels. [5]   As it happens, CBD has been demonstrated to have both anti-inflammatory and antiangiogenic effects. [6] [7]   Additionally, a 2020 study looked at the effects of CBD on isolated human keratinocytes. The researchers found that cannabidiol affected the cells’ differentiation, leading them to conclude that it could be useful for treating various skin disorders. [8]   CBD, The Endocannabinoid System, and Your Skin Researchers theorize that the potential benefits of CBD in treating psoriasis may come from its interaction with the body’s endocannabinoid system (ECS).   The ECS consists of three parts: endocannabinoids produced by our bodies, the enzymes that make and break them down, and cannabinoid receptors (CB1 & CB2).   CBD interacts with the ECS in two major ways:   Suppressing an enzyme (FAAH) that breaks down the endocannabinoid anandamide, boosting its levels and prolonging its effects [9]   Altering the function of the CB1 receptor [10]   Discovered only recently, this important system plays a role in regulating everything from brain function to immunity to maintaining what’s called homeostasis — a state of internal balance. [11]   Each component of the ECS can also be found in the skin — your largest organ — with growing evidence that this system may be involved in maintaining skin health.   In particular, studies have shown that the ECS is involved in skin cell proliferation, differentiation, survival, and immune responses, all of which can play a role in psoriasis. [12]   There’s also an indication that malfunction of the ECS may be associated with the development of skin conditions, including psoriasis. [13] For example, one study found that people with psoriasis and a related condition called psoriatic arthritis had elevated endocannabinoid levels in various blood cells. [14]   The bottom line is that the ECS may play an essential role in skin health and the processes that underlie psoriasis and other skin conditions. Although dosages, timing, and method of intake are yet to be determined for effective treatment, the preliminary evidence suggests that using CBD may have a positive effect on psoriasis and its symptoms through its effect on the ECS.   Anandamide and the Skin When it comes to the role of the ECS on skin health, the endocannabinoid anandamide may be particularly interesting.   One study found that it reduced the release of pro-inflammatory molecules called cytokines by immune cells in the skin, a process that seems to be involved in causing psoriasis and other inflammatory skin conditions. [15]   There’s also proof that anandamide can reduce itching — one of the symptoms of psoriasis — as demonstrated by a study where suppressing the FAAH enzyme reduced the itching response in mice. [16]   As we highlighted earlier, CBD has the same effect on this enzyme and can result in increased anandamide levels. As such, increasing anandamide levels could be a major factor in how CBD may help treat psoriasis.   Additionally, a recent 2020 review paper summarizing the results of various studies on the effects of anandamide, THC, CBD, and other cannabinoids, concluded that they all may have an important role in reducing skin inflammation, cell proliferation, fibrosis, pain, and itching, all of which may help with treating psoriasis and other skin conditions. [17]   What Does the Research Say? There isn’t much human or clinical research looking at the use of CBD for treating psoriasis patients.   One 2019 Italian study examined the effects of a CBD-infused ointment on 20 people with psoriasis, eczema, or scarring as a result of these conditions. The study participants applied the ointment to affected skin areas two times a day for 90 days.   The treatment improved the symptoms and severity of psoriasis and several measures of skin health, such as elasticity and hydration. [18]   The researchers concluded that applying CBD topically is a safe and effective way to improve the quality of life in people with skin disorders.   Although these findings are promising, more high-quality studies, and especially randomized controlled trials (RCTs) — the gold standard of clinical research — are needed.   How Much CBD Should I Take for Psoriasis? There isn’t enough research to suggest the ideal CBD dosage for psoriasis. This is especially true when applying CBD topically since most studies use either capsules or CBD oil.   Besides, CBD dosage can vary depending on genetic factors, the type of product you’re using, and other variables.   Your best option is to start by applying the amount of CBD recommended by your topical product to the affected skin areas.   If you don’t notice any effects after a few days or weeks, you can try to raise the dose, making sure to try it for at least a few days before raising again if needed.   If you’re using a topical product, you can estimate your CBD dose by dividing the total CBD content by the container volume.   For example, if a 30 ml cream contains 600 mg of CBD, that’s 20 mg per ml. Next, you can estimate how much of an ml of the product you’re using to arrive at your estimated CBD dose.   Are There Any Side Effects? One of the great things about CBD is that it’s a remarkably safe compound. Although it can cause some side effects, they are relatively mild in nature and have only been reported by studies using high dosages. [19]   More importantly, CBD and hemp's other cannabinoids can only produce side effects when they reach the bloodstream.   When applied topically in the form of a cream, ointment, or another product, CBD and other cannabinoids are highly unlikely to penetrate deep enough into the skin to reach the blood.   Having said that, other ingredients in topical CBD preparations — such as terpenes or fragrances — may cause allergic reactions or other adverse effects in rare cases. [20]   Conclusion More research is needed to show that CBD or other cannabinoids can provide relief for psoriasis. In particular, high-quality human studies are lacking, and most of the findings are restricted to test-tube studies.   Nonetheless, the current evidence suggests that CBD may help alleviate psoriasis symptoms and address its underlying causes, such as an overactive immune response in the skin and a rapid build-up of keratinocyte cells.   Given that it’s relative safety — especially when applied topically — CBD represents a promising, natural option for alleviating psoriasis. This is especially true for cases where standard pharmaceutical treatments are either ineffective or produce significant side effects.   References [1]  Lowes, Michelle A., Mayte Suárez-Fariñas, and James G. Krueger. "Immunology of psoriasis." Annual review of immunology 32 (2014): 227-255.   [2] Rendon, Adriana, and Knut Schäkel. "Psoriasis pathogenesis and treatment." International journal of molecular sciences 20.6 (2019): 1475.   [3]  Tiwari, V., & Brent, L. H. (2019). Psoriatic Arthritis.   [4]  Wilkinson, Jonathan D., and Elizabeth M. Williamson. "Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis." Journal of dermatological science 45.2 (2007): 87-92.   [5]  Norooznezhad, Amir Hossein, and Fatemeh Norooznezhad. "Cannabinoids: Possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation." Medical Hypotheses 99 (2017): 15-18.   [6]  Atalay, Sinemyiz, Iwona Jarocka-Karpowicz, and Elzbieta Skrzydlewska. "Antioxidative and anti-inflammatory properties of cannabidiol." Antioxidants 9.1 (2020): 21.   [7]  Solinas, M., et al. "Cannabidiol inhibits angiogenesis by multiple mechanisms." British journal of pharmacology 167.6 (2012): 1218-1231.   [8]  Casares, Laura, et al. "Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1." Redox biology 28 (2020): 101321.   [9]  Leweke, F. M., et al. "Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia." Translational psychiatry 2.3 (2012): e94-e94.   [10]  Chung, Hery, Angélica Fierro, and C. David Pessoa-Mahana. "Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study." PloS one 14.7 (2019): e0220025.   [11]  Skaper, Stephen D., and Vincenzo Di Marzo. "Endocannabinoids in nervous system health and disease: the big picture in a nutshell." (2012): 3193-3200.   [12]  Bíró, Tamás, et al. "The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities." Trends in pharmacological sciences 30.8 (2009): 411-420.   [13]  Tóth, Kinga Fanni, et al. "Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C (ut) annabinoid” System." Molecules 24.5 (2019): 918.   [14]  Ambro?ewicz, Ewa, et al. "Pathophysiological alterations of redox signaling and endocannabinoid system in granulocytes and plasma of psoriatic patients." Cells 7.10 (2018): 159.   [15]  Chiurchiù, Valerio, et al. "Anandamide suppresses proinflammatory T cell responses in vitro through type-1 cannabinoid receptor–mediated mTOR inhibition in human keratinocytes." The Journal of Immunology 197.9 (2016): 3545-3553.   [16]  Schlosburg, Joel E., et al. "Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus." Journal of Pharmacology and Experimental Therapeutics 329.1 (2009): 314-323.   [17]  Cintosun, Amber, Irene Lara-Corrales, and Elena Pope. "Mechanisms of Cannabinoids and Potential Applicability to Skin Diseases." Clinical Drug Investigation (2020): 1-12.   [18]  Palmieri, B., C. Laurino, and M. Vadalà. "A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars." Clin Ter 170.2 (2019): e93-e99.   [19]  Iffland, Kerstin, and Franjo Grotenhermen. "An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies." Cannabis and cannabinoid research 2.1 (2017): 139-154.   [20]  Nath, Neel Som, et al. "Contact allergy to hydroperoxides of linalool and D-limonene in a US population." Dermatitis 28.5 (2017): 313-316.

  Scientific Confidence Grade Effect Size Rating Editorial Note C ** CBD may help with sleep disorders by targeting their underlying causes. However, most of the current evidence is limited to animal and low-quality human studies. The available human research evidence is promising but of relatively low quality. Research suggests that CBD may significantly improve sleep problems.   CBD for Sleep Disorders: Can It Help? (October 2020) Early human studies suggest that cannabidiol (CBD) may improve sleep disorders. Researchers believe it works by influencing our endocannabinoid system and addressing the underlying causes of sleep problems, such as anxiety.   We’ve all dealt with occasional sleeplessness and other sleep-related issues. However, when these problems become a regular occurrence, you may be suffering from a sleep disorder, such as insomnia.   While these conditions can be treated, standard medications often come with unwanted side effects and cannot be used long-term.   Besides, many drugs only treat the symptoms of sleep disorders — such as difficulty falling asleep —  rather than the underlying causes. As a result, there’s increasing interest in alternative, natural solutions like cannabis and CBD.   There’s some evidence that CBD can help with insomnia and other sleep disorders, particularly by targeting their underlying causes. Read on for a look at what researchers say about CBD’s potential to aid healthy sleep.   Sleep Disorders Overview Sleep disorders affect your sleeping patterns and make it difficult to get the right amount of quality sleep. They can decrease the quality of life and harm your overall health, particularly through sleep deprivation.   There are many types of sleep disorders, but insomnia — difficulty falling and staying asleep — is the most common. Sleep disorders typically manifest as excessive daytime drowsiness due to a lack of quality sleep at night.   Sleep Disorder Subtypes Sleep disorders can be grouped into several types: [1]   Insomnia: the most common type of sleep disorder, characterized by difficulty falling and staying asleep.   Breathing related sleep disorders: sleep apnea and other disorders linked to difficulty breathing during sleep.   Hypersomnia: conditions such as narcolepsy and idiopathic hypersomnia that make it difficult to stay awake during the day. People with these disorders can fall asleep at any time.   Parasomnia: disorders characterized by abnormal behaviors when you’re falling asleep, sleeping, or waking up, such as sleepwalking and sleep terrors.   Circadian rhythm sleep disorders: sleep disorders where your body’s internal 24-hour sleep-wake clock is out of sync with your environment’s light-dark cycle, causing you to feel disoriented and sleepy.   Sleep Movement disorders: conditions that make it difficult to get restful sleep by causing movements, such as restless leg syndrome and bruxism.   Sleep Disorder Symptoms & Pathology The most common symptom of sleep disorders is excessive daytime sleepiness and associated problems such as difficulty concentrating, irritability, and feeling very tired.   Depending on the exact type, sleep disorders can also cause movement during sleep, irregular breathing, and other issues.   Can CBD Help With Sleep Disorders? Alleviating insomnia and improving overall sleep quality is one of the most common reasons people turn to CBD products. What’s so promising about CBD is that it seems to work by tackling the underlying causes of sleep disorders instead of just their symptoms.   For example, anxiety, depression, and other conditions such as post-traumatic stress disorder, are known to either cause or contribute to insomnia and other sleep problems. [2] [3]   Preliminary studies have suggested that CBD may help alleviate anxiety, PTSD, and possibly have antidepressant-like effects as shown in a mouse study. [4] [5]   That means people whose sleep issues are related to these conditions can potentially benefit from CBD. Anxiety, in particular, is one of the leading causes of insomnia.   Similarly, chronic pain is another reason many people struggle to get good sleep. In this case, CBD’s pain-relieving properties may be beneficial. [6]   Another interesting finding is that CBD may have a biphasic effect on sleep. This means that low doses of CBD at certain times may actually promote wakefulness, as demonstrated by a study in rats. [7] Furthermore, higher doses of CBD may act as a sedative, as shown by a small study on humans, where 160 mg doses increased total sleep time and reduced sleep disturbances. [8]   These preliminary findings merit further research to confirm whether CBD can be taken at night to promote sleep or be used in lower doses during the day to counteract the excessive daytime sleepiness caused by most sleep disorders.   Not to mention, it's unclear how much of an effect other hemp properties - such as flavonoids and terpenes - have on sleep.   The Endocannabinoid System and Sleep We also know that the body’s endocannabinoid system (ECS) plays an important role in regulating the sleep-wake cycle.   This crucial system helps your body maintain a balanced state called homeostasis by regulating a wide range of essential processes, such as immunity, metabolism, and brain function. [9]   The ECS consists of endocannabinoids made in our bodies, the enzymes that build and break them down, and the cannabinoid receptors (CB1 & CB2) they activate.   The most popular theory is that the ECS plays a role in the effects of the suprachiasmatic nucleus — the part of the brain which controls an individual’s 24-hour circadian rhythm — on sleep and other processes. [10] This means the ECS may help maintain and promote sleep.   Researchers are working hard to clarify the connection between the ECS and sleep. A study in rats revealed that the levels of endocannabinoids, their associated enzymes, and even cannabinoid receptors appear to fluctuate throughout the day, with a marked difference between the day and night. [11]   The results from a study of healthy humans showed that levels of the endocannabinoid anandamide are three times higher when waking up versus going to sleep and that this relationship is dysregulated by sleep deprivation. [12]   Furthermore, there’s evidence that activation of CB1 receptors via THC — the main intoxicating cannabinoid —  can promote sleep. This may begin to describe the correlation between people feeling sleepy after taking cannabis with high levels of THC. [13]   A study in rats also found a strong correlation between the light-dark cycle, sleep, and levels of ECS components. Specifically, CB1 receptor density increased in the pons area of the brain during REM rebound — the period of increased REM sleep that follows sleep deprivation. [14]   Taken together, all of these findings suggest that our endocannabinoid system plays an important role in regulating our sleep cycle and making sure we get enough sleep.   Since more and more evidence is showing how CBD can interact with this system in various ways (e.g., by suppressing the enzyme that breaks down anandamide, altering the function of the CB1 receptor), CBD may provide a possible avenue to help with sleep disorders. [15] [16]   What Does the Research Say? There’s a growing volume of human research suggesting that CBD can help with sleep disorders.   One 2019 study out of Colorado looked at the effects of CBD on 72 people with anxiety and poor sleep. CBD decreased anxiety in 79% of the study participants for all three months of treatment.   Sleep was improved in 67% of the subjects during the first month but fluctuated for the remaining two months. [17]   A different study of 21 adults with PTSD reported that 38% experienced improvements in sleep after taking CBD. [18]   There are also multiple case reports of individuals who improved their sleep by taking CBD.   One such report discussed the cases of four Parkinson’s disease patients with REM sleep behavior disorder (RBD), a type of parasomnia characterized by acting out vivid, violent dreams during rapid eye movement (REM) sleep.   All four patients experienced a significant improvement in RBD after taking CBD. [19]   Another case report discussed a woman with restless leg syndrome (RLS) who relieved her symptoms and improved sleep by using CBD oil. [20] Finally, a case report of a ten-year-old girl with PTSD noted that CBD oil improved her insomnia. [21]   In short, the available human research evidence of CBD’s positive effects on sleep disorders is promising. Having said that, there’s a lack of high-quality evidence and the type of rigorous research needed like randomized controlled trials (RCTs), to confirm findings and provide specific therapeutic guidance on the use of CBD for improving sleep.   How Much CBD Should I Take for Sleep? There’s no consensus on the right amount of CBD to take to promote good sleep. There simply isn’t enough research in this area.   Besides, your ideal CBD dosage for sleep or any other issue depends on many variables, such as body weight, genetics, symptom severity, and the type of product you’re using. As such, it’s hard to suggest a CBD dosage that will work for everyone.   If you’re new to CBD, it’s best to start with a small dose (10-15 mg) and see how it makes you feel. If you don’t notice any effect, you should gradually raise the dosage over a few hours or days, making sure to stop in between doses to see if you feel anything.   Once you find the CBD dose that provides you with the relief you’re looking for, stick to it. Also, keep in mind that it’s best to take CBD about 20-60 minutes before sleep to give it time to start working.   Some products are (such as CBD gummies and tinctures) make it easier to measure out doses. We highly suggest finding a CBD product that's designed for sleep aid.   Are There Any Side Effects? According to numerous research studies, CBD is a generally safe substance with few side effects and was even tolerated well at daily dosages as high as 1500 mg. [22]   Although CBD can cause issues such as tiredness, drowsiness, diarrhea, dry mouth, low blood pressure, dizziness, and changes in appetite or weight, these effects are relatively mild and have only been reported by studies using very high doses of pure CBD (300 mg and up). [23]   Most people take no more than 100 mg of CBD at a time, so they’re unlikely to experience these side effects. Additionally, instead of pure CBD, many individuals use whole-plant, full-spectrum CBD extracts which have been shown to have a lower risk of side effects. [24]   Conclusion Although more high-quality research is needed, early findings suggest that CBD oils can have a beneficial effect on sleep problems and full-on sleep disorders such as insomnia.   This isn’t all that surprising as CBD:   Interacts with the endocannabinoid system, which is known to regulate the sleep-wake cycle   May improve many of the health issues that can cause or worsen sleeping problems, such as chronic pain, anxiety, and depression   Although figuring out the right CBD dosage can take some experimentation, CBD is a safe, natural substance with few and minor side effects.   In comparison, many of the prescription medications used for sleep disorders cannot be used in the long-term due to significant adverse effects and the possibility of addiction and withdrawal. Not to mention, CBD products for sleeping are often made with a number of other sleep-promoting all-natural ingredients, such as melatonin.   References [1] Chokroverty, Sudhansu. "Overview of sleep & sleep disorders." Indian J Med Res 131.2 (2010): 126-140. [2] Oh, Chang-Myung, et al. "The effect of anxiety and depression on sleep quality of individuals with high risk for insomnia: a population-based study." Frontiers in neurology 10 (2019): 849. [3] Maher, Michael J., Simon A. Rego, and Gregory M. Asnis. "Sleep disturbances in patients with post-traumatic stress disorder: epidemiology, impact and approaches to management." CNS drugs 20.7 (2006): 567-591. [4] Masataka, Nobuo. "Anxiolytic effects of repeated cannabidiol treatment in teenagers with social anxiety disorders." Frontiers in Psychology 10 (2019): 2466. [5] Sales, Amanda J., et al. "Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels." Progress in Neuro-Psychopharmacology and Biological Psychiatry 86 (2018): 255-261. [6] Vu?kovi?, Sonja, et al. "Cannabinoids and pain: new insights from old molecules." Frontiers in pharmacology 9 (2018): 1259. [7] Murillo-Rodríguez, Eric, et al. "The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent." Behavioral neuroscience 122.6 (2008): 1378. [8] CARLINI, ELISALDO A., and JOMAR M. CUNHA. "Hypnotic and antiepileptic effects of cannabidiol." The Journal of Clinical Pharmacology 21.S1 (1981): 417S-427S. [9] Skaper, Stephen D., and Vincenzo Di Marzo. "Endocannabinoids in nervous system health and disease: the big picture in a nutshell." (2012): 3193-3200. [10] Babson, Kimberly A., James Sottile, and Danielle Morabito. "Cannabis, cannabinoids, and sleep: a review of the literature." Current psychiatry reports 19.4 (2017): 23. [11] Valenti, M., et al. "Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain." Cellular and Molecular Life Sciences CMLS 61.7-8 (2004): 945-950. [12] Vaughn, Linda K., et al. "Endocannabinoid signalling: has it got rhythm?." British journal of pharmacology 160.3 (2010): 530-543. [13] Murillo-Rodríguez, Eric. "The role of the CB1 receptor in the regulation of sleep." Progress in Neuro-Psychopharmacology and Biological Psychiatry 32.6 (2008): 1420-1427. [14] Martnez-Vargas, M., et al. "Sleep modulates cannabinoid receptor 1 expression in the pons of rats." Neuroscience 117.1 (2003): 197-201. [15] Leweke, F. M., et al. "Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia." Translational psychiatry 2.3 (2012): e94-e94. [16] Chung, Hery, Angélica Fierro, and C. David Pessoa-Mahana. "Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study." PloS one 14.7 (2019): e0220025. [17] Shannon, Scott, et al. "Cannabidiol in anxiety and sleep: a large case series." The Permanente Journal 23 (2019). [18] Elms, Lucas, et al. "Cannabidiol in the treatment of post-traumatic stress disorder: a case series." The Journal of Alternative and Complementary Medicine 25.4 (2019): 392-397. [19] Chagas, Marcos HN, et al. "Cannabidiol can improve complex sleep?related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series." Journal of clinical pharmacy and therapeutics 39.5 (2014): 564-566. [20] Megelin, Thomas, and Imad Ghorayeb. "Cannabis for restless legs syndrome: a report of six patients." Sleep medicine 36 (2017): 182. [21] Shannon, Scott, and Janet Opila-Lehman. "Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: a case report." The Permanente Journal 20.4 (2016). [22] Bergamaschi, M. M., R. H. Queiroz, and A. W. Zuardi. "en Crippa, JA (2011). Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent." Current Drug Safety 6.4: 237-249. [23] Huestis, Marilyn A., et al. "Cannabidiol adverse effects and toxicity." Current neuropharmacology 17.10 (2019): 974-989. [24] Pamplona, Fabricio A., Lorenzo Rolim da Silva, and Ana Carolina Coan. "Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis." Frontiers in neurology 9 (2018): 759.