5 BEST CBD Vape Pens
Best of 2025

Top 5 Best CBD Vape Pens

Different Kinds of CBD Vape Pens

CBD vape pens are handheld devices designed for vaporizing CBD e-liquid. They come in two main types:

The Classic Battery and Atomizer Combo

These vapes allow for continued use by refilling them with fresh CBD e-liquid. They require a rechargeable battery—typically a standard 510-thread device—and either pre-filled cartridges or refillable tanks. While they involve a bit more setup, they offer more flexibility and variety in CBD options.

Refillable pens last longer since you only need to replace the cartridges or refill the tank, making them budget-friendly over time. They also provide more customization with different CBD formulations and flavors.

Conviently Disposable CBD Vape Pens

These are single-use vapes that come pre-loaded with CBD e-juice. Each pen has a built-in battery and atomizer, making it a ready-to-use option. Once the CBD liquid runs out, the entire device is discarded. Most disposable pens provide several hundred puffs before depletion, offering a simple, no-maintenance way to vape CBD.

CBD disposable vape pens are ideal for those new to cannabidiol vaping. With no upfront commitment, they allow you to try vaping without investing in a rechargeable setup. If you decide CBD vaping isn’t for you, there’s nothing left to maintain or replace.

What Do CBD Vape Pens Do?

CBD vape pens provide effects similar to CBD oils, edibles, and other CBD products. The main difference is the way CBD enters your body. When you vape, CBD is absorbed through the lungs and reaches your bloodstream much faster than other methods.

Because of this, vaping delivers effects almost instantly. Many people prefer vape pens for situations where quick relief is needed. For instance, some users find vaping helpful for managing sudden anxiety attacks or other conditions that require fast-acting support.

Beyond speed, vaping also allows for more controlled dosing. Since the effects are felt within minutes, users can take small puffs and adjust their intake based on how they feel. This makes it easier to find the right amount of CBD without the risk of taking too much at once.

Are There Health Benefits to CBD Vape Pens?

Currently, more research is needed before the Food and Drug Administration (FDA) can approve CBD vape pens for specific health benefits or medicinal use. However, many users report positive effects, and early studies suggest that CBD may offer several therapeutic benefits.

Anxiety

Studies using advanced brain imaging have shown that CBD may help reduce anxiety by influencing mood-regulating brain receptors. Because of this, researchers are exploring its potential as treatment for conditions like depression, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). Many users also claim that vaping CBD provides fast-acting relief during moments of heightened anxiety.

Epilepsy and Seizures

The FDA has approved Epidiolex, a prescription CBD-based medication, for managing epilepsy and seizures. Research on CBD’s anticonvulsant properties dates back to the 1970s. However, its potential became widely known after Charlotte Figi, a young girl with Dravet syndrome, experienced a dramatic reduction in seizures—from over 1,200 per month to just a few—after using CBD. Her case helped bring attention to CBD as a possible option for seizure management.

Inflammation

CBD is known to have anti-inflammatory properties, which is why many people use it to help with pain relief. While formal studies continue, individuals dealing with chronic pain, arthritis, and muscle soreness have reported noticeable improvements after using CBD.

Insomnia

One of CBD’s few side effects is drowsiness, especially at higher doses. Because of this, researchers have explored its potential as a sleep aid. Some studies suggest that CBD may help with insomnia, and many users report it promotes relaxation and leads to a better night’s sleep.

Side Effects from Chemotherapy

Preliminary research suggests that CBD may help reduce the side effects of chemotherapy, such as nausea and vomiting. While some studies also indicate that CBD may inhibit cancer cell growth, more research is needed to understand its full potential in cancer treatment. For now, many patients use CBD alongside conventional treatments to help ease discomfort.

CBD Vape Pens Dosage Recommendation

Determining the exact dosage of CBD from a vape pen can be challenging since each puff may contain a different amount of cannabidiol. Some companies provide estimates based on the total CBD content in a cartridge or pen, but precise tracking remains difficult.

If you’re new to vaping CBD, start with a low dose and gradually increase it. Begin with 2 to 3 puffs, then wait a few minutes to see how you feel. If you don’t experience the desired effects, increase to 5 or 6 puffs, then 8 to 10, adjusting as needed.

CBD effects everyone differently. Factors such as body weight, metabolism, and tolerance can influence how CBD interacts with your system.

To give you a better idea of how CBD will affect you based on body weight, you can refer to our chart:

Furthermore, if you use CBD regularly, you may develop a tolerance over time, meaning you might need higher-strength products to achieve the same effects.

Additionally, if you take prescription medication, consult your doctor before using CBD. While uncommon, CBD may interact with certain medications, potentially altering their effects. Always prioritize safety when adding CBD to your routine.

Potential Side Effects and Concerns with CBD Vape Pens

Vaping CBD products raises concerns because you’re inhaling chemicals into your lungs. While research has shown that vaping is generally safer than smoking, the longer-term effects are still not fully understood.

In recent years, the cannabis industry has faced increased scrutiny after vaping products led to hospitalizations, with some cases being fatal. Investigations revealed that Vitamin E acetate, a compound found naturally in the body and some foods, was the cause of these health issues.

While Vitamin E is safe when consumed orally, it can be harmful when vaporized and inhaled. This issue stemmed from less reputable companies putting out products that didn’t meet safety standards.

How We Choose the Best CBD Vape Pens

To ensure we provide the best CBD vape pens, we created a strict set of criteria. If you’re considering buying CBD products elsewhere, we recommend using a similar approach:

Certificate of Analysis (CoA)

Since the CBD market lacks regulation, brands are responsible for ensuring the quality and safety of their products. A reliable way to verify this is through third-party lab testing.

The results of these tests are provided in a Certificate of Analysis (CoA). By reviewing a brand’s CoA, you can determine the cannabinoid profile and check for harmful contaminants, such as heavy metals and pesticides.

Customer Reviews

To understand how a CBD oil vape pen might affect you, customer reviews are invaluable. These reviews offer real-life insights into how the product made other users feel. All the vape pens on our list have positive feedback from customers, which reflects their reliability and effectiveness.

Ingredients

The e-liquid in a CBD vape pen typically contains propylene glycol (PG) and vegetable glycerin (VG). These ingredients are considered safer than traditional smoke, though long-term effects are still being studied.

Some products may also contain additional active ingredients (i.e. melatonin) and flavorings. Always check the ingredients list to ensure the product meets your dietary needs. If you have lung issues, such as asthma, it may be wise to avoid vaping altogether.

Extract Type

CBD vape pens are available in three primary extract types:

• Full-spectrum — Contains all the cannabinoids and phytonutrients found in the hemp plant.
• Broad-spectrum — Similar to full-spectrum, but with the tetrahydrocannabinol (THC) removed.
• Isolate — The purest form of CBD, typically 99% or more.

We’ve focused on full-spectrum and broad-spectrum extracts for our list. While we didn’t find a reputable CBD isolate vape pen, there are other isolate options available in e-juice and cartridges for those interested in pure CBD.

Potency

CBD vape pens vary in potency, which is measured in milligrams (mg). A higher milligram count generally means a stronger effect. We included a variety of potencies on our list to cater to different needs, ensuring a broad selection for different users.

Final Word

CBD vape pens provide a fast and efficient way to experience the potential benefits of CBD, from managing anxiety to promoting better sleep. While research is still evolving, many users have reported positive outcomes, with some studies suggesting CBD’s effectiveness in addressing conditions like inflammation and insomnia.

However, it’s important to remain cautious, as vaping (like any other inhalation method) carries risks that require careful consideration. Always ensure the products you choose come from reputable brands that adhere to safety standards, including third-party lab testing and transparent ingredient lists.